General Application & Access Information
for
Mouse Whole Genome Linkage Scans
General Application & Access Information
for
Mouse Whole Genome Linkage Scans
All investigators requesting access to the CIDR genotyping facility must prepare an application to be evaluated by the CIDR Access Committee (CAC) and the Board of Governors (BOG). The CAC is a standing NIH committee comprised of scientists who have expertise in gene mapping and genetic dissection of complex diseases. The CAC evaluates an application for the likelihood that a genome scan will lead to the successful identification of genes contributing to the trait.
The BOG is comprised of the Directors of the thirteen supporting institutes or their designees. The BOG meets the month after the meeting of the CAC and makes the final decision about which projects are accepted for genotyping. This decision is based primarily on the CAC's recommendation, but the BOG's assessment of the significance of the project as well as the genotyping capacity of CIDR will also be factors. The BOG, in consultation with the CIDR Principal Investigator and the Genotyping Lab Director, sets the queue for projects entering CIDR.
Extramural NIH grantees supported by a participating institute require prior approval from the institute liaison before submitting an application to CIDR. Intramural NIH investigators should contact Dr. Camilla Day before preparing an application.
It is preferable for investigators to have all the samples collected before applying to CIDR. In the event that all samples are not in hand by the application due date, the application will be accepted for review as long as the principal investigator provides data regarding phenotypic characterization. If access to CIDR is granted, the investigator will receive a letter verifying CIDR's commitment to perform the genotyping. All investigators will receive feedback from the CAC that details the basis for its recommendation.
The primary criterion used by the CIDR Access Committee (CAC) is the likelihood that the proposed project will successfully map the trait. Since projects granted access to CIDR may exceed the genotyping capabilities of the Center, the CAC will prioritize the successful projects. In reaching these decisions, the Committee will evaluate each of the following: