CIDR performs whole genome SNP linkage scan genotyping using Illumina's HumanLinkage-12 Genotyping BeadChip. With this technology, 12 samples per BeadChip are assayed for 6,000 SNP loci in a single experiment.

HumanLinkage-12 Marker Panel
• 6,090 SNP markers
• 0.58 cM average spacing covering the genome
• Average marker heterozygosity:
     • 0.43 in Caucasians
     • 0.38 in African Americans
     • 0.36 in Asians

Statistical Genetics Consultation
As an additional, unique option, CIDR offers to investigators the opportunity to consult on study design and statistical analysis. Investigators requesting such collaborations with CIDR scientists should detail these collaborations in their application and include appropriate letters of commitment from those involved. Investigators seeking more information on potential collaboration should contact Dr. Camilla Day at NHGRI. Such consultations need to be requested and planned well in advance. Collaboration with statistical genetics consultants incurs no additional charge for approved projects.

References
Kemlink D, Plazzi G, Vetrugno R, Provini F, Polo O, et al. (2008) Suggestive evidence for linkage for restless legs syndrome on chromosome 19p13. Neurogenetics Jan 10:[Epub ahead of print].

Capon F, Reece A, Ravindrarajah R, Chung E (2006) Linkage of monogenic infantile hypertrophic pyloric stenosis to chromosome 16p12-p13 and evidence for genetic heterogeneity. American Journal of Human Genetics 79(2):378-382.

Amos, C., Chen, W.V., Lee, A., Li, W., Kern, M., Lundsten, R., et al. (2006). High-density SNP analysis of 642 Caucasian families with rheumatoid arthritis identifies two new linkage regions on 11p12 and 2q33. Genes and Immunity, 7, 277-286.