Investigators are required to have all samples collected and all subjects phenotyped before applying to CIDR for GWAS genotyping.

All investigators requesting access to the CIDR genotyping facility must prepare an application to be evaluated by the CIDR Access Committee (CAC) and the Board of Governors (BOG).

Step 1 — Contact Institute Liaison
Before submitting an application, extramural grantees must obtain approval from the supporting NIH Institute Liaison, and discuss the NIH data sharing policy (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-07-088.html). Discussion should include subject consents relevant to data sharing, whether reconsenting may be required, and what phenotypic measures will be shared. Intramural NIH investigators should contact Dr. Camilla Day before preparing an application. Contact should be made at least two months prior to submitting an application.

Step 2 — Application Submission    (Download an Application)

Deadlines:		March 1, July 1, November 1
CAC Review:		May, September, January
BOG Decisions:		June, October, February

GWAS applications must include a Data Dictionary of phenotypic measures to be shared and a Data Summary summarizing the data collected.

Step 3 — Application Review & Notification of Access
The CIDR Access Committee (CAC) reviews genotyping applications three times a year. The primary criterion used by CAC is the likelihood that the dataset will provide power to map a significant association between a trait and a causal genetic variant. In reaching their decisions, reviewers evaluate each of the following:

• Significance and complexity of the trait and the need for a high-throughput GWAS with the particular array selected
• Quality and completeness of phenotyping and exposure measures to be included
• Strength of the evidence for a genetic component for the trait and the anticipated size of a detectable genetic effect
• Appropriateness of the study design and population for the specific trait mapping project
• Power of the sample set to detect a genetic effect
• Plans for data management and data analysis
• Plans for follow-up studies to identify the genetic variant(s)

Questions about the application process can be addressed to Dr. Camilla Day.