Investigators are required to have all samples collected and all subjects phenotyped before applying to CIDR for GWAS genotyping.

All investigators requesting access to the CIDR genotyping facility must prepare an application to be evaluated by the CIDR Access Committee (CAC) and the Board of Governors (BOG).

Step 1 — Contact Institute Liaison
Before submitting an application, extramural grantees must obtain approval from the supporting NIH Institute Liaison, and discuss the NIH data sharing policy (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-07-088.html). Discussion should include what phenotypic measures will be shared and subject consents relevant to data sharing. Intramural NIH investigators should contact Dr. Camilla Day before preparing an application. Contact should be made at least two months prior to submitting an application.

Step 2 — Application Submission Information
All CIDR applications must be submitted electronically as an X01. A program announcement (PAR) describing the application submission requirements can be found at: http://grants.nih.gov/grants/guide/pa-files/PAR-08-258.html. Some suggested guidelines for the Research Design and Methods Section are found here.

Note that GWAS applications must include a Data Dictionary of phenotypic measures to be shared and a Data Summary summarizing the data collected.

Step 3 — Application Review & Notification of Access
Applications are accepted via continuous receipt (http://grants.nih.gov/grants/guide/notice-files/NOT-HG-09-015.html) and will be reviewed by the CIDR Access Committee (CAC) no later than 120 days after receipt. Click here for the application review schedule. The primary criterion used by CAC is the likelihood that the dataset will provide power to map a significant association between a trait and a causal genetic variant. (Details about the review criteria are provided in the PAR.)

Approximately one month after the CAC review, the CIDR Board of Governors (BOG) meets. The BOG is comprised of the Directors of the fourteen supporting institutes or their designees. The BOG makes the final decision about which projects are accepted for genotyping. This decision is based primarily on the CAC's recommendation, but the BOG's assessment of the significance of the project and the genotyping capacity of CIDR will also be factors.

Questions about the application process can be addressed to Dr. Camilla Day.