General Application & Access Information
for
Human Whole Genome SNP Linkage Scans
General Application & Access Information
for
Human Whole Genome SNP Linkage Scans
All investigators requesting access to the CIDR genotyping facility must prepare an application to be evaluated by the CIDR Access Committee (CAC) and the Board of Governors (BOG). The CAC is a standing NIH committee comprised of scientists who have expertise in gene mapping and genetic dissection of complex diseases. The CAC evaluates an application for the likelihood that a genome screen will lead to the successful mapping of genes contributing to the trait.
The BOG is comprised of the Directors of the thirteen supporting institutes or their designees. The BOG meets the month after the meeting of the CAC and makes the final decision about which projects are accepted for genotyping. This decision is based primarily on the CAC's recommendation, but the BOG's assessment of the significance of the project and the genotyping capacity of CIDR will also be factors. The BOG, in consultation with the CIDR Principal Investigator and the Genotyping Lab Director, sets the queue for projects entering CIDR.
Extramural NIH grantees supported by a participating institute require prior approval from the institute liaison before submitting an application to CIDR. Intramural NIH investigators should contact Dr. Camilla Day before preparing an application.
Investigators are not required to have all the samples collected before applying to CIDR. Investigators who plan to apply for NIH funding in order to initiate mapping projects can apply for access to CIDR before submitting an NIH grant application. If access to CIDR is granted, the investigator will receive a letter verifying CIDR's commitment to perform the genotyping. See Application Deadlines for guidance about the timing of submission. All investigators will receive feedback from the CAC that details the basis for its recommendation.
CIDR recommends that the number of data releases for any one project be limited to one or, at most, two releases. It has become clear that rapid changes in technology can make it difficult to merge data collected over an extended time period. Two releases are appropriate for projects such as those with a very large sample number and those with a study design that uses the data from the second release to replicate results from the first scan. CIDR will not be responsible for merging data from multiple data releases and requires that, if multiple releases are requested, the application include information about the strategy for merging the two data sets.
CIDR requires that projects with multiple collection sites coordinate submission of samples and related family information through a single point of contact.
The primary criterion used by the CIDR Access Committee (CAC) is the likelihood that the proposed project will successfully map the trait. Since projects granted access to CIDR may exceed the genotyping capabilities of the Center, the Board of Governors will prioritize the successful projects. In reaching these decisions, the CAC will evaluate each of the following: