CIDR

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General

The Center for Inherited Disease Research (CIDR) is a valuable national resource for cutting-edge genetic research. CIDR was established at the Johns Hopkins University in 1996. CIDR provides high quality next generation sequencing and genotyping services to investigators working to discover genes that contribute to disease. On-site statistical geneticists provide valuable insight into analysis issues as they relate to study design, data production and quality control. In addition, CIDR has a consulting agreement with the University of Washington Genetics Coordinating Center (GCC) to provide statistical and analytical support, most predominantly in the areas of GWAS data cleaning and methods development. Completed studies encompass over 175 phenotypes across 530 projects and 620,000 samples. The impact is evidenced by over 380 peer-reviewed papers published in 100 journals.

graph of completed studies

In response to the expanding field of genetics, CIDR rapidly implements new technologies, offers new services and increases throughput while maintaining strict quality standards.

Support and Access

The CIDR facility is supported by several sources. The largest source of support is the NIH CIDR Program, a federal contract from the National Institutes of Health to the Johns Hopkins University funded by fourteen NIH institutes: NHGRI, NCI, NEI, NIA, NIAAA, NIAMS, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIMH, and NINDS. The CIDR contract was initially awarded in 1996 and renewed in 2007 and 2012 with some overlap of funding. The federal contract numbers are:

N01-HG-65403 (1996-2008)

$72,505,388

HHSN268200782096C (2007-2012), and HHSN268201100011I (2011-2012)

$69,082,344

HHSN268201200008I (2012-2017)

$101,892,223

Dr. Kim Doheny, Lead Co-Principal Investigator

Dr. David Valle, Co-Principal Investigator

Dr. Alan Scott, Co-Principal Investigator

Dr. Elizabeth Pugh, Co-Investigator

The most recent contract for the NIH CIDR Program, High Throughput Genotyping and DNA Sequencing for Studying the Genetic Contributions to Human Disease, was awarded June 1, 2012 and is funded by individual Task Orders. Dr. Lawrence Brody of the National Human Genome Research Institute (NHGRI) is the Government Scientific Officer. Projects that are actively being worked on at CIDR are supported by the contracts awarded in 2007, 2011 and/or 2012.

News Articles regarding the CIDR Program Renewal:

The Johns Hopkins Center for Inherited Disease Research Receives $101 Million
This is a Johns Hopkins Medicine News Release

NIH Renews Johns Hopkins' CIDR with $100M
This is a GenomeWeb article and is accessible to GenomeWeb subscribers only

CIDR is also supported through additional grant awards such as multiple NHGRI-led Genome-Wide Association Study Consortia (U01HG004438, GENEVA, eMERGE, GARNET) and as a Center for Mendelian Genomics (U54HG006542, Baylor-Johns Hopkins Center for Mendelian Genetics).

CIDR contracts and grants support the costs of genotyping studies through an application, review and approval process.

CIDR also provides genotyping to both Johns Hopkins and outside investigators as a direct fee-for-service, requiring no application or approval process.

For more information on options for access to CIDR services please see our Access page.

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